Input sequence

Protein name E3 ubiquitin-protein ligase highwire
Organism Drosophila melanogaster Length 5233
Disorder content 23.1% ProS content 8.1%
IDEAL NA UniProt Q9NB71

Prediction

Order Disorder ProS BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP SEG:LCR COILS:coiledCoil 0 5233 1-23 24-27 28-52 53-121 122-134 135-205 206-233 234-301 302-306 307-310 311-539 540-545 546-691 692-695 696-794 795-802 803-942 943-949 950-1285 1286-1291 1292-1361 1362-1365 1366-1416 1417-1421 1422-1424 1425-1589 1590-1601 1602-1745 1746-1771 1772-1885 1886-1905 1906-1964 1965-1971 1972-2001 2002-2016 2017-2172 2173-2175 2176-2201 2202-2326 2327-2340 2341-2372 2373-2386 2387-2472 2473-2499 2500-2581 2582-2598 2599-2625 2626-2629 2630-2870 2871-2908 2909-3003 3004-3020 3021-3107 3108-3176 3177-3204 3205-3403 3404-3421 3422-3518 3519-3536 3537-3541 3542-3548 3549-3597 3598-3670 3671-4014 4015-4176 4177-4207 4208-4228 4229-4233 4234-4359 4360-4366 4367-4375 4376-4404 4405-4435 4436-4484 4485-4511 4512-4631 4632-4663 4664-4677 4678-4688 4689-4689 4690-4803 4804-4808 4809-5233 1-23 53-121 135-205 234-301 311-539 546-691 696-794 803-942 950-1285 1292-1361 1366-1416 1425-1589 1602-1745 1772-1885 1906-1964 1972-2001 2017-2172 2202-2326 2341-2372 2387-2472 2500-2581 2599-2625 2630-2870 2909-3003 3021-3107 3177-3204 3404-3421 3519-3536 3542-3548 3598-3670 4015-4176 4208-4228 4234-4359 4376-4404 4436-4484 4512-4631 4664-4677 4690-4803 4809-5233 28-52 122-134 206-233 307-310 943-949 1417-1421 1590-1601 1746-1771 1886-1905 1965-1971 2002-2016 2176-2201 2327-2340 2373-2386 2473-2499 2582-2598 2871-2908 3004-3020 3108-3176 3205-3403 3422-3518 3537-3541 3549-3597 3671-4014 4177-4207 4360-4366 4405-4435 4485-4511 4632-4663 4689-4689 28-36 129-134 206-213 943-949 1746-1762 1768-1771 2009-2016 2198-2201 2327-2340 2373-2381 2582-2593 2900-2908 3148-3163 3379-3403 3422-3430 3448-3454 3461-3493 3518-3518 3537-3541 3583-3588 3708-3723 3737-3747 3760-3802 3808-3866 3883-3905 3927-3974 3986-3991 4654-4663 4689-4689 1434-1587 2015-2168 961-1049 597-783 1434-1587 2015-2170 974-1061 589-741 4976-5073 1436-1587 2024-2168 985-1031 984-1031 1436-1587 2014-2169 961-1062 596-793 4215-4349 2917-2999 4969-5067 602-1049 2815-2991 4146-4351 4984-5054 44-64 141-152 169-184 193-202 212-221 291-298 798-810 878-892 933-940 1063-1080 1241-1257 1281-1302 1355-1366 1420-1433 1480-1497 1648-1657 1738-1766 2336-2350 2387-2415 2489-2503 2619-2636 2872-2883 3133-3154 3181-3212 3223-3236 3340-3371 3583-3597 3725-3744 3905-3932 4204-4211 4412-4437 4543-4552 4634-4652 3177-3204 3gbwA(7-158) 1e-46 65.58% 3hwjA(3-146) 4e-34 47.4% 4jhnA(228-320) 1e-12 48.94% 3kciA(139-330) 2e-08 26.26% 3gbwA(7-158) 8e-42 65.58% 3hwjA(3-148) 4e-36 46.79% 1a12A(4-92) 1e-17 37.08% 4l1mA(16-159) 3e-05 27.27% 4aycA(41-130) 9e-06 24.27% PF08005(1-153) 3e-19 41.29% PF08005(9-152) 4e-09 33.11% PF00415(1-49) 1e-05 48.98% PF00415 5e-07 33.9% PF08005 8.9e-87 298.9% PF08005 4.7e-93 319.7% 1a12A(94-198) 4e-21 36.19% 1a12A(151-370) 1e-13 15.86% 1jhjA(20-159) 2e-11 16.55% 1v05A(12-95) 1e-05 16.67% 1jm7B(3-93) 8e-05 12.0% b.69.5 1e-54 185.7% b.1.18 2.6e-06 20.8% b.18.1 1.3e-29 97.9% g.44.1 7.5e-10 30.5%

Sequence

MVGLLNPLKYGDHFYELYTNSTRRKMQHDRKVLTKRKSRKDKSAAAMAAAAAAAVLEGNA
GAGGLVNPLDPPLVKEQLMILPSFPVAHIELDPNASKFAVFSAIRSTVLEAETRYSLFQE
GGAPSGQSGSNQKKWSNNVNSACCMMCAHSCMISNLLDCSCHAHMAMHGAVGPGNAGPGG
PVGVLVDGRIPAPVPVVVGGPGLPAEKRPRRDSANSDADSDTEEPTEREPVYATVPLIVG
AGLRSLFELIADARHVHPLLCTKALKALLDVIQGQQPESFKLEPEELINPLYDLLLDLAT
MPAALNSATGAEANWSAMACAALLGLCIARGDTGKMLKAIAAMLMTPRQLSAQIVQLPVV
LATLQHTVISAALNKPTRPDFHSHGVPHNSLIDEFPVKLPPLSTGAPITSPAMACDGVFV
YLLYGGTLLKIGTGFGGSYKGHIYAQNEDFSHERSAWLGYSGGQLYFRRTCRRSAGDQLQ
MVGLDTLAIKAMSPLSMLHMREGLNYVLFTDDDSLHAICSNRDDTLVVKKLNLYHNSYNI
DPPPFELPLQLARKKFRTLGYAAFEDELLNQYQIQRIQSAHNSFEPKLPAPCRDADVDVM
GMACGKEFGLVRASNGRVYYYGKSAALGLKCVGRTPTLKLTELVISKAANIVHVAVGHDG
IHALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGTSA
FVTKTGKLIMYGKDTAHCDAMGFVSELLEQHVTKVALGKAHCVALNAKGQLFSFGLNNKG
QCGRIFNKLQPVKDVPPFASSSTAAACFASLLPLDKRLKLDFSTLCDYDDHNLVQGQCRV
CVICRECTGYNVSCVSALNVPLDQRLAGSICPCGHGDAGCAKCGLCAACIALQDSDEAKT
ELKPPPSDVQQRQQRSKTLIMRRKERKGELETGAAGGGAATPTDLDKDPPRVAPLAPQLL
QLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAISQ
VAAGSNHTVLLTSKGMVYTFGNYQKGQLGRLPSDYGLKPPPQDDDSPVGAGSDGGAGGSP
TVAPVGMPGPERSQSPANVQPSGSKEMPPLLPVLTQRQKFLWNCSPGAVFGLGPCYGKKV
TWIGANGDQTFIKIDESLITAQMLPKMHVVANKKTILLIPSIPLSFHTLSINRRDGSCTA
HYRGQTNFVKLMQAQPEQQQPEINSNLDVAVTPVADSPAHASTSSLLAALTGTATAGVPI
NEQMSRSMHEARNQIFEEQLPEVGSSAAAAAVAAPGTPVSAGSVPRSRRGGKQGTSSPEP
IPSPPQLAFTMDPTYNVLWVFDGAARKLRCHNVVASDINDSDANAATYRSLLSPELSLPD
RVDSRVARSQASLNLLACLDILTSAQDNIPGCFEQPLLKQTQQTAETQAGEFQVVNRFDN
FGGGWGYSGHSVEAIRFSADTDIVICGFGMFGGRGEYSCKLKLFDLGGDGGGYEKEGILI
SETKEVPYECGARSKHHILLPKPVSAVAGRWYLVWARIAGPSSDCGSCGQASVTTEDQVV
FSFKSSKKANNGTDVNSGQIPAILYRLVTQDCKQTPAQMDADPVQRISRAFANSVSRECF
ESLVVLLSWSWDCFKLQLREERDRSRPLQLQQSLQYLGYVIKSCLRLLRKYTIEIYPQRN
SSTSVATGGGSNAAHGSGVVTTAKSVQSKPNKDKNTPRVVGNAGVMAKYFGDPSTSVAPA
MISSASSGGAPSTSASAAVAPGSGTPVTRKTNMENIQLAECIGNVRALLIGIFCDDIFKD
IATDEGYELSLEILDECHLSFVACFDAFYPTSSLKWNCLCDLLAQMDRGALHSRLLSAIL
AGLCSPSVKLRATFSLLSAAGNERQSIISPSDNSGLPMLSSTDAHPYPVLVEQMIYRTQQ
EKSDFLSNSWTFKDVLVRLLDIIASPIRSRIEAIYSRSLGSLGYPGGKDCVNQGLIDNCC
HLLARVLAEIVYQTAMGEYDKLFMPPRTLHSTGARFARCDVSRTWNTGNFGPDAIAFAVD
RPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQHKWETLESVSGSYDQDAVHNDLAEI
KFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGAQFHFYACDLSFNGTTPARG
QLPCILYYSTPMKQDGHSASGRTGDGSNVATHLEDRIMLLGPHEVSTRDTALQIAADITK
KCTELLILARNAMAASCSPSDNSSNHTQTIDSEHNITPIEEHMDINWANNSRTAALPTAI
DPQLSTARDLGKRIESFSKGLMETLKFDKRSTNPFEMEIEIGATEVEESADLRNGQSQSV
SQSQSQSQSVPINGNERTADFEFAEQSAQQSMPQHLHSDSEEAPLEVAGMAAGGGVSVAD
GSGGVAGVGSQAAAVQLLEVFNLAASNMFHTLLPLVYAHIANLACSDPKSSVQILGLIKE
ILPHIAALNQLHVSKDQRQPEPAIFATQTSGSGNSNSSSTTSNHYCVVESDHPYKSASIS
SYRVEFPPCVQWLTIEFDPQCGTAQLEDYLLLSIPMRPASQAPPVPHVDDYLEQADNNVN
GAGDRRRNTGGGIAGSGAAPNTHQRSASVQLTMASCCRSPGCGNAPGSAAAPSSMPLRSQ
DPNDREWIVVKKFNTASTWLHNVLILPGNCVEFSLETASLYAQDPHNNRYGFKCLVVGYD
NPTSINASNSCLIRLEQELAYLGGMCSANLMKKELNLPDDKDVEDMSGIEETINTHHTLL
SKGFALSEPQLTVHQALESYLPIGSQSNERQFLKDFISGAPGSSGARLAAWLQPESRLDP
NKCELNTITEPLRYGWPSQVTVTIRDQYGDAVLVPELKVEIKAIPTGSGPNGSATGTGTS
CTSVAEVSAPGPNLWMRRASRDTWGWGGMAPPPRINYEPTVKDKMVFKAITFMKPYANYS
FEELRYASPVQTRVTELLNAKDMEDGTFSVQWTPSSVGAYCLAVTIDGIPLEEVYRVDVK
EGILPPPTQRNSAQRRPQAPSKLRRFQARHSSGLRIRSHPTLQSEQVGVVRVGGVISFID
EIENDDGVWLRLSTESIRQHCTMGWYPTEAWCLQFNQHLARMLLQPVTDKEVNPVRKGVG
AEEDVEEQPPVTPSASGEASPEPEPDPSPVLSPAKTKPGRFLSGHQSTNPFLYPAKHADL
AEREAQVQEEREKEEEQVDDEDADDREPEQEALPAVELLPAHIGSAIAGVVGGGAIKLQA
LQKWFKGDAVDGPQPLTPSHSPPLAGVSVRELVRAMGGQDSPRGNGNRSQQEQDPEFSLA
SMRRPNYSASQTAALLSTPKHTPKRSAVVASETSGLEDELSLLQITTTTTGQGEQQSELQ
LATTSTASSASKRNPMGPIKRAMPPSFAESIRAVFAALLWHEGVVHDAMACASFLKFHPG
LPKEGATVVTRRGESGDPRLQLSREQKAQQRHSVEVANAGNYLNIRPSTLETLTKSGNCS
LHNRSKYRKNLLSGGGGAINSGDDTAQKLQALPEMVSVLPPALRCLVYLWEQICSGCVQI
VQSNALEQREPRLLSPGSRDLNGDADTEGKEGKNSDQASAGEKDLGRKCKRKKKDDGSWC
EICELFLPMPVTYHMRIAHPGCGKSAKGKGYNSVGIFCEGWAGNCGEGGKGASSWFLMCD
PCRDRYLASCRSANNINSAARQLESSAAEGNELNLFGVKSTTLIANAEVYTTMRENATFL
LELCSSSSSASGAAGSLAATSSSSKRSPQQMSVVAMPVVIEHQLGNSDLKPSTSRCSRMA
RLSGSKFCPGVGSGAFRKSFVGGPPTAPENVWLAPESFACLECLGTAGHEDLPYEMFGLG
PNSNDNGYDRPLSEISYESCEPNNYDMLSGSLAPGTTAAASVGGGNLSKFHRSYSMGQGW
ASLAQHNHPPPHHPQQQHHQQQQMNLQLQQHQAPPVDGQPKVVYRRRNNSTSEGDGSLLI
CYPSEHLRRLVPQKLLASVSVMQTASGEGTGKDHATGTLGLDQSAGQNGGGNLLLTRPAM
AFITQKHELDRLRAAMRRSLRIAACRIYALQALNWLLRSVTQGVCLHDLMWWFVSSLNPT
GGHQPVERGEEASEPALEHPVAYTQISGRFAHLITQSLHVFLQSVADLTLHLPLGSPLQR
VAIQCFGIRFRQADHQFLHSSHVFGNISKILSKSDEQNDAMAVSTILKPDCDVEHNQVHS
VATGGSSGAGARLLCYTDLAGMFEVTVSSRPAMAESLTDNSTETFWESDEEDRNKCKIIE
LSLTKLNYACRYLLVHIDNSRDIQNKVLNVVFYAGQSLGDTNIIKSADVDPKACSWISAK
ICDDSCTHFRLELHGPENTLRVRQIKLLGLPIGGAVGSDDSSDHKHQPHLRLSHASRIQQ
QICEAETLRVFRLITGQVFGKLISNVSSDLVPPDSAGIGPPSGGAASTSLLADSLDLREH
MVGILFSRSKLSHLQKQVIVHIVHAIRKEAQRAKEDWELANLAHVLKQSPQQQTAPALAA
SASCESTPERSRAPDTYCFEMLSMVLALSGSVVGRSYLSQQHGLLRDLLGLLHTGSDRVQ
RQVTALLRRILPEITPESFAELLGVQRLPPADYSIAHQSASDFDMSRLGLLDIFLAVIAK
SLQLQVKVKTTVASTGPSGSGGVSGSSSGNGGAVLKAGQQEKTPAFVRLWSSLDLSVQQL
RSRPPTGEPGTTDPFQFDALPPRKESKRNLNQRWFLNGVISTKQAESIISLIRDLASGKL
SEKWSQITKAAIAESVLNLTRLEEIYRSPEHCTKTSTLWLALASLCVLERDHVEKLSSGQ
WSKLCDTRPLCSNHDDGETAAIIQCETCGSLCGDCDRFLHLNRKTRSHKRTVCKEEEEAI
RVELHESCGRTKLFWLLALADSKTLKAMVEFRDGSHTIISGPQEAVGRCRFCGLTGNSGL
LEIGNVCADAQCQEYAANSCLKTKPCGHACGGVTGERKCLPCLQHVCHTRENELAEELRD
PKLTQDADDMCMICFVEALSCAPSIHLECGHVFHYHCCKAVLEKRWSGPRITFGFSLCPI
CKADIQHPLLSDILEPINGLKQDVKRKALMRIKYEGVVKDTDSKNVNMTQLAMDRYAYYV
CFKCQKAYYGGEARCDAEIGEKFDPEELVCGGCSDVARAQMCPKHGTDFLEYKCRYCCSV
AVFFCFGTTHFCDTCHDDFQRLTNIPKVKLPQCPAGPKAKQLLGDECPLHVMHPPTGEEF
ALGCGVCRNAQTF

Region:1-5233
Length:5233aa
Label:Full sequence
Reset:click