Input sequence

Protein name Ryanodine receptor 2
Organism Homo sapiens Length 4967
Disorder content 14.1% ProS content 5.8%
IDEAL NA UniProt Q92736

Prediction

Order Disorder ProS BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP HMMER:SCOP HMMER:SCOP SEG:LCR TMHMM:TMhelix 0 4967 1-10 11-85 86-97 98-102 103-106 107-378 379-391 392-467 468-477 478-960 961-967 968-1070 1071-1086 1087-1289 1290-1294 1295-1319 1320-1413 1414-1493 1494-1501 1502-1746 1747-1750 1751-1854 1855-1888 1889-2012 2013-2055 2056-2352 2353-2378 2379-2448 2449-2456 2457-2796 2797-2800 2801-2816 2817-2851 2852-2855 2856-2908 2909-2918 2919-2946 2947-2951 2952-2985 2986-3001 3002-3343 3344-3349 3350-3431 3432-3461 3462-3642 3643-3661 3662-3700 3701-3720 3721-3860 3861-3865 3866-4198 4199-4241 4242-4246 4247-4279 4280-4318 4319-4481 4482-4525 4526-4555 4556-4678 4679-4690 4691-4796 4797-4801 4802-4963 4964-4967 11-85 98-102 107-378 392-467 478-960 968-1070 1087-1289 1295-1319 1414-1493 1502-1746 1751-1854 1889-2012 2056-2352 2379-2448 2457-2796 2817-2851 2856-2908 2919-2946 2952-2985 3002-3343 3350-3431 3462-3642 3662-3700 3721-3860 3866-4198 4242-4246 4280-4318 4482-4525 4556-4678 4691-4796 4802-4963 1-10 86-97 379-391 468-477 961-967 1071-1086 1290-1294 1320-1413 1494-1501 1747-1750 1855-1888 2013-2055 2353-2378 2449-2456 2801-2816 2852-2855 2909-2918 2947-2951 2986-3001 3344-3349 3432-3461 3643-3661 3701-3720 4199-4241 4247-4279 4319-4481 4526-4555 4679-4690 4964-4967 4-10 93-97 379-386 468-477 961-967 1071-1086 1290-1294 1320-1361 1370-1392 1747-1750 1878-1888 2024-2039 2353-2370 2801-2813 2852-2855 2947-2951 2994-3001 3344-3349 3454-3461 3643-3646 3712-3720 4247-4279 4379-4394 4541-4545 4964-4967 10-544 660-1277 1405-1562 2701-2905 3581-3607 9-544 660-1318 2700-2905 1087-1671 2582-2791 3581-3607 4486-4657 4032-4085 4380-4599 13-214 3830-3955 2701-2791 861-947 976-1068 2821-2905 456-648 2123-2325 1099-1207 753-800 235-372 226-406 451-655 670-808 861-955 975-1069 1098-1221 1423-1561 2121-2332 2700-2794 2820-2908 3465-3960 4333-4599 4690-4866 230-396 730-946 2708-2940 869-1094 2519-2601 3299-3450 1037-1233 1396-1567 3958-4084 230-405 4032-4089 701-719 1319-1330 1873-1892 2371-2381 2417-2427 2498-2511 3701-3721 4219-4228 4253-4281 4340-4351 4360-4378 4414-4459 4767-4785 4844-4862 4280-4302 4499-4518 4571-4593 4710-4732 4767-4789 4848-4867 4jkqA(1-499) 0.0 93.27% 4uweA(583-1109) 0.0 56.05% 4uweA(1047-1181) 2e-40 53.8% 4etvA(1-183) 7e-90 85.37% 2bcxB(1-27) 7e-07 88.89% 4uweA(1-523) 0.0 67.41% 4uweA(583-1171) 0.0 51.09% 4uweA(1792-1973) 4e-126 59.22% 4uweA(584-1169) 6e-75 18.35% 4uweA(1806-1973) 9e-41 22.17% 2bcxB(1-27) 7e-08 88.89% 1k8kE(2-171) 2e-07 13.87% 2fceA(11-65) 2e-06 27.27% PF06459(47-270) 5e-38 45.61% PF08709(5-218) 1e-33 43.64% PF08454(4-114) 5e-31 56.35% PF02026(2-92) 6e-26 54.95% PF02026(1-87) 1e-23 56.32% PF02026(2-94) 2e-21 45.16% PF02026(2-92) 1e-16 47.25% PF01365(5-194) 2e-24 39.59% PF01365(2-182) 2e-23 34.29% PF00622(2-107) 1e-05 31.25% PF00622(66-113) 0.001 41.67% PF02815(1-130) 8e-05 24.46% PF02815 8.8e-82 282.3% PF01365 1.3e-96 331.5% PF00622 1.4e-36 132.1% PF02026 1.3e-62 218.6% PF02026 1.3e-62 218.6% PF00622 4.5e-43 153.7% PF00622 3.3e-34 124.2% PF01365 3.7e-84 290.2% PF02026 2.1e-64 224.6% PF02026 1.7e-35 128.5% PF08454 2.8e-274 921.7% PF06459 5.7e-132 449.0% PF00520 1.3e-07 35.8% 1n4kA2(1-132) 2e-34 17.26% 1a8iA(235-452) 2e-22 15.22% 1b7eA(1-239) 2e-21 7.11% 1b7eA(1-238) 2e-15 6.67% 2i76A1(10-102) 7e-20 12.9% 1ak6A(21-172) 8e-20 14.37% 2fnjA1(10-214) 1e-15 12.84% 2fbeA1(15-182) 2e-06 11.54% 1ij5A(100-230) 3e-10 17.39% b.42.6 1.5e-70 234.8% a.39.1 2.1e-11 35.8%

Sequence

MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL
LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD
LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH
MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV
TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV
CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR
STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR
ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL
IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL
LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF
LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD
DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE
NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY
KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL
GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK
VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI
QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG
TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF
KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG
FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ
VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG
GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK
PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN
VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR
NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI
KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ
CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV
DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP
DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK
EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE
SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH
RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK
DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK
KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR
ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN
LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY
LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML
VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG
NGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG
RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF
CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL
CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL
RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL
SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN
FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY
KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG
YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK
EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI
LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE
KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF
LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED
LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI
YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP
MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA
VFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFT
TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV
VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI
CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD
TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVV
ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR
VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME
KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY
LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF
RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE
QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ
DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF
LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY
EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG
SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM
QLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLS
LKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVE
GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIF
GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE
KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY
NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYV
LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ
PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS
DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA
AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD
TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA
IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF
FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN

Region:1-4967
Length:4967aa
Label:Full sequence
Reset:click