Input sequence

Protein name Nicastrin
Organism Homo sapiens Length 709
Disorder content 5.4% ProS content 3.4%
IDEAL NA UniProt Q92542

Prediction

Order Disorder ProS BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam HMMER:Pfam RPS-BLAST:SCOP HMMER:SCOP SEG:LCR TMHMM:TMhelix 0 709 1-25 26-264 265-270 271-692 693-696 697-700 701-709 26-264 271-692 697-700 1-25 693-696 701-709 6-25 693-696 42-662 54-662 275-466 274-499 249-502 255-502 4-16 413-432 638-653 670-692 4upcA(1-409) 1e-169 63.61% 4upcA(3-409) 6e-106 61.74% PF05450(2-199) 1e-59 70.5% PF05450 4.5e-133 452.7% 1cp7A(60-273) 1e-13 14.57% c.56.5 8.4e-12 35.7%

Sequence

MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY

Region:1-709
Length:709aa
Label:Full sequence
Reset:click