Input sequence

Protein name E3 ubiquitin-protein ligase HUWE1
Organism Homo sapiens Length 4374
Disorder content 43.1% ProS content 13.3%
IDEAL NA UniProt Q7Z6Z7

Prediction

Order Disorder ProS BLAST:PDB BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP SEG:LCR COILS:coiledCoil 0 4374 1-14 15-208 209-217 218-395 396-400 401-477 478-497 498-707 708-760 761-873 874-883 884-964 965-1062 1063-1069 1070-1083 1084-1089 1090-1095 1096-1183 1184-1187 1188-1219 1220-1227 1228-1290 1291-1311 1312-1358 1359-1431 1432-1500 1501-1514 1515-1517 1518-1568 1569-1574 1575-1682 1683-1740 1741-1743 1744-1849 1850-1863 1864-1915 1916-1989 1990-1994 1995-2059 2060-2096 2097-2101 2102-2165 2166-2170 2171-2190 2191-2194 2195-2203 2204-2207 2208-2260 2261-2651 2652-2657 2658-2682 2683-2710 2711-3059 3060-3064 3065-3173 3174-3239 3240-3298 3299-3305 3306-3320 3321-3357 3358-3426 3427-3444 3445-3448 3449-3470 3471-3572 3573-3578 3579-3636 3637-3732 3733-3741 3742-3764 3765-3792 3793-3839 3840-3871 3872-3876 3877-3895 3896-3948 3949-3974 3975-3977 3978-4374 15-208 218-395 401-477 498-707 761-873 884-964 1063-1069 1084-1089 1096-1183 1188-1219 1228-1290 1312-1358 1432-1500 1518-1568 1575-1682 1744-1849 1864-1915 1990-1994 2060-2096 2102-2165 2171-2190 2208-2260 2652-2657 2683-2710 3060-3064 3174-3239 3299-3305 3321-3357 3427-3444 3449-3470 3579-3636 3733-3741 3765-3792 3840-3871 3877-3895 3949-3974 3978-4374 1-14 209-217 478-497 708-760 874-883 965-1062 1070-1083 1291-1311 1359-1431 1501-1514 1569-1574 1683-1740 1916-1989 1995-2059 2097-2101 2195-2203 2261-2651 2658-2682 2711-3059 3065-3173 3240-3298 3306-3320 3358-3426 3471-3572 3637-3732 3742-3764 3793-3839 3896-3948 3975-3977 1-6 492-497 753-760 988-991 1045-1062 1070-1083 1424-1431 1510-1514 1699-1709 1725-1729 1944-1952 1972-1989 2343-2348 2359-2366 2408-2417 2462-2523 2540-2547 2555-2582 2588-2592 2603-2630 2643-2651 2658-2682 2855-2861 2893-2907 2957-2990 3018-3043 3065-3101 3107-3115 3130-3159 3240-3245 3282-3298 3385-3396 3534-3537 3637-3651 3680-3686 3704-3711 3719-3732 3742-3764 3801-3814 3975-3977 3992-4366 1310-1356 3980-4366 1310-1356 1599-1686 430-814 4068-4374 104-367 1617-1678 86-374 424-815 1317-1355 1609-1680 4067-4374 3992-4366 1617-1678 3950-4033 1310-1357 56-638 1311-1358 3942-4033 4014-4367 92-103 721-734 887-901 1052-1066 1083-1104 1319-1325 1397-1424 1526-1542 1841-1864 2015-2031 2052-2063 2130-2142 2261-2271 2275-2292 2347-2357 2408-2470 2526-2542 2590-2600 2678-2701 2738-2758 2761-2781 2909-2932 2944-2959 3030-3048 3090-3107 3172-3181 3223-3238 3248-3263 3372-3382 3444-3459 3480-3550 3748-3760 3780-3808 3831-3856 3915-3931 2683-2710 3765-3792 3h1dA(13-382) 0.0 98.13% 2ekkA(1-47) 3e-11 89.36% 3h1dA(2-382) 5e-69 94.57% 2ekkA(1-47) 3e-12 89.36% 2dk6A(2-94) 4e-09 23.71% PF06025(2-365) 1e-89 48.33% PF00632(1-297) 2e-76 49.52% PF06012(16-308) 2e-44 41.08% PF02825(8-68) 2e-09 43.55% PF06012 6e-146 495.4% PF06025 3.8e-212 715.3% PF00627 9.3e-10 43.0% PF02825 5.9e-10 43.7% PF00632 6.1e-180 608.4% 1nd7A(2-372) 9e-108 41.07% 2a90A2(2-68) 9e-16 26.87% 1pu1A(9-91) 2e-09 27.06% 1ifyA(5-48) 2e-05 34.69% a.118.1 1.2e-05 15.2% a.5.2 6.5e-08 29.6% d.266.1 0.00089 14.2% d.148.1 6.6e-130 390.0%

Sequence

MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI
LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP
VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ
RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL
KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV
LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG
SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH
AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI
LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV
LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH
AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL
PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA
PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR
QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP
MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK
PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ
QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA
MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT
DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL
PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL
LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF
DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML
TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET
KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS
TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG
SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN
AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL
QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR
DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE
LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL
GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG
LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ
GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ
EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR
EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD
DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV
RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL
LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT
LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE
ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE
TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET
TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS
EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS
RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS
TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA
LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL
LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI
ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI
FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN
CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE
TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA
SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA
TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED
AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET
LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ
KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR
EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER
PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV
RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE
THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH
VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL
FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS
VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE
ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID
DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI
QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA

Region:1-4374
Length:4374aa
Label:Full sequence
Reset:click