Input sequence

Protein name E3 ubiquitin-protein ligase HUWE1
Organism Mus musculus Length 4377
Disorder content 45.0% ProS content 13.4%
IDEAL NA UniProt Q7TMY8

Prediction

Order Disorder ProS BLAST:PDB BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP SEG:LCR COILS:coiledCoil 0 4377 1-14 15-143 144-158 159-208 209-220 221-395 396-400 401-474 475-495 496-706 707-761 762-833 834-837 838-874 875-882 883-884 885-911 912-916 917-963 964-1058 1059-1069 1070-1082 1083-1088 1089-1095 1096-1118 1119-1123 1124-1217 1218-1225 1226-1290 1291-1311 1312-1357 1358-1433 1434-1500 1501-1512 1513-1567 1568-1575 1576-1679 1680-1740 1741-1744 1745-1850 1851-1858 1859-1862 1863-1901 1902-1907 1908-2062 2063-2095 2096-2100 2101-2104 2105-2190 2191-2195 2196-2201 2202-2206 2207-2261 2262-2647 2648-2681 2682-2682 2683-2710 2711-3059 3060-3065 3066-3076 3077-3080 3081-3084 3085-3092 3093-3174 3175-3237 3238-3340 3341-3344 3345-3461 3462-3471 3472-3602 3603-3617 3618-3626 3627-3636 3637-3717 3718-3763 3764-3765 3766-3793 3794-3843 3844-3874 3875-3882 3883-3890 3891-3952 3953-4011 4012-4015 4016-4377 15-143 159-208 221-395 401-474 496-706 762-833 838-874 885-911 917-963 1059-1069 1083-1088 1096-1118 1124-1217 1226-1290 1312-1357 1434-1500 1513-1567 1576-1679 1745-1850 1863-1901 2063-2095 2105-2190 2207-2261 2648-2681 2683-2710 3060-3065 3077-3080 3085-3092 3175-3237 3341-3344 3462-3471 3603-3617 3627-3636 3718-3763 3766-3793 3844-3874 3883-3890 3953-4011 4016-4377 1-14 144-158 475-495 707-761 875-882 912-916 964-1058 1070-1082 1291-1311 1358-1433 1501-1512 1568-1575 1680-1740 1851-1858 1908-2062 2096-2100 2196-2201 2262-2647 2682-2682 2711-3059 3066-3076 3081-3084 3093-3174 3238-3340 3345-3461 3472-3602 3618-3626 3637-3717 3764-3765 3794-3843 3891-3952 4012-4015 1-6 156-158 492-495 752-761 964-966 1001-1004 1043-1058 1070-1082 1375-1379 1509-1512 1724-1728 1908-1912 1944-1952 1974-1994 2399-2406 2454-2505 2510-2524 2529-2532 2544-2580 2607-2617 2643-2647 2682-2682 2711-2714 2735-2740 2822-2826 2842-2846 2895-2909 2957-2961 2967-2989 3018-3042 3057-3059 3066-3076 3081-3084 3093-3102 3108-3115 3134-3159 3238-3244 3268-3274 3282-3306 3320-3340 3345-3359 3387-3396 3427-3461 3579-3602 3618-3626 3637-3646 3682-3685 3705-3713 3764-3765 3811-3816 3891-3896 4012-4015 3995-4369 1317-1356 3983-4369 1315-1356 1599-1690 430-814 4071-4377 104-367 1617-1678 86-374 424-815 1317-1355 1609-1680 4070-4377 3995-4369 1617-1678 3953-4036 1326-1357 56-638 1311-1358 3945-4036 4017-4370 92-103 721-734 841-858 887-901 1052-1066 1083-1104 1292-1314 1319-1325 1397-1424 1526-1542 1699-1710 1841-1864 2052-2063 2130-2142 2261-2271 2275-2292 2347-2357 2408-2470 2526-2542 2590-2600 2678-2701 2738-2758 2765-2780 2913-2932 2944-2959 2993-3007 3030-3048 3090-3107 3172-3181 3223-3238 3253-3263 3369-3383 3445-3460 3475-3552 3749-3761 3784-3793 3837-3859 3918-3934 2683-2710 3766-3793 3h1dA(13-382) 0.0 98.13% 2ekkA(8-47) 7e-11 100.0% 3h1dA(2-382) 5e-69 94.57% 2ekkA(6-47) 4e-11 95.24% 2dk6A(2-98) 1e-09 23.76% PF06025(2-365) 1e-89 48.33% PF00632(1-297) 2e-76 49.52% PF06012(16-308) 2e-44 41.08% PF02825(8-68) 2e-09 43.55% PF06012 5.1e-148 502.3% PF06025 2.9e-213 719.1% PF00627 9.3e-10 43.0% PF02825 5.9e-10 43.7% PF00632 6.1e-180 608.4% 1nd7A(2-372) 9e-108 41.07% 2a90A2(2-68) 9e-16 26.87% 1pu1A(9-91) 2e-09 27.06% 1ifyA(16-48) 4e-05 42.42% a.118.1 1.4e-05 15.0% a.5.2 6.5e-08 29.6% d.266.1 0.00089 14.2% d.148.1 6.6e-130 390.0%

Sequence

MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
FDGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
ECCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI
LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP
VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ
RPSTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL
KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV
LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG
SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH
AAEEASSEDEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI
LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV
LQEGLLQLDLILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH
AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL
PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLA
PMETDEPSSSDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR
QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP
MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRK
PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEEAGQEEGGSRREPQVNQQ
QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSEEDQMMRAIA
MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT
DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL
PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL
LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF
DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML
TLLRVPRLSKNSKSSNGQELEKTLEESKETDIKHKENKGNDIPLALESTNTEKEASLDET
KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS
TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG
SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN
AVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGGTTQEVGQLL
QDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVFAADGAPAETSTTGTSQGEASTPEETR
EGKKDKEGDRTSEEGKQKSKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE
LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL
GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG
LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ
GASQDSSSHQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ
EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR
EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD
DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV
RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL
LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT
LSSIPTALTRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLAEE
ETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSESKE
TLGTLQPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEAET
TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSS
EQPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGADS
RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRSAPS
SNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA
LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL
LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI
ETPKLSTSEERGKKSSKSCASSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI
FQIQRSGGRKHTEKHASSGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN
CESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSSGGEG
ETSPHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEVQTNSSNS
GSSTAATSNTSTTTTTTTTATAPTPTPPAATTPVTSAPALVAATAISTITVAASTTVTTP
TTATTTVSTSTTKGSKSPAKVGEGGSGIDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLE
DAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCE
TLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTST
QKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMV
REGQRARRQQQAATSESSNQSETSVRREESPMDVDQPSPSAQDTQSIVISDGTPQGEKEK
EEKPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESK
PPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLR
FAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDM
AVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPM
YALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHIL
GKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANIL
VTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI
DIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGM
NGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA

Region:1-4377
Length:4377aa
Label:Full sequence
Reset:click