Input sequence

Protein name E3 ubiquitin-protein ligase HERC2
Organism Homo sapiens Length 4834
Disorder content 17.8% ProS content 9.1%
IDEAL NA UniProt O95714

Prediction

Order Disorder ProS BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam RPS-BLAST:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam HMMER:Pfam RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP RPS-BLAST:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP HMMER:SCOP SEG:LCR COILS:coiledCoil 0 4834 1-66 67-73 74-77 78-92 93-157 158-188 189-269 270-276 277-319 320-365 366-383 384-387 388-845 846-856 857-896 897-948 949-976 977-1014 1015-1032 1033-1048 1049-1071 1072-1079 1080-1195 1196-1202 1203-1264 1265-1268 1269-1289 1290-1295 1296-1352 1353-1384 1385-1462 1463-1469 1470-1538 1539-1542 1543-1549 1550-1606 1607-1705 1706-1710 1711-1754 1755-1759 1760-1768 1769-1810 1811-1818 1819-1824 1825-1835 1836-1853 1854-1859 1860-1930 1931-1952 1953-2005 2006-2010 2011-2122 2123-2131 2132-2184 2185-2195 2196-2295 2296-2303 2304-2346 2347-2375 2376-2416 2417-2465 2466-2510 2511-2547 2548-2631 2632-2636 2637-2769 2770-2774 2775-2925 2926-2934 2935-3327 3328-3333 3334-3364 3365-3545 3546-3554 3555-3565 3566-3600 3601-3614 3615-3741 3742-3745 3746-3800 3801-3807 3808-3909 3910-3913 3914-4322 4323-4340 4341-4369 4370-4377 4378-4409 4410-4439 4440-4802 4803-4834 1-66 74-77 93-157 189-269 277-319 366-383 388-845 857-896 949-976 1015-1032 1049-1071 1080-1195 1203-1264 1269-1289 1296-1352 1385-1462 1470-1538 1543-1549 1607-1705 1711-1754 1769-1810 1819-1824 1836-1853 1860-1930 1953-2005 2011-2122 2132-2184 2196-2295 2304-2346 2376-2416 2466-2510 2548-2631 2637-2769 2775-2925 2935-3327 3334-3364 3546-3554 3566-3600 3615-3741 3746-3800 3808-3909 3914-4322 4341-4369 4378-4409 4440-4802 67-73 78-92 158-188 320-365 384-387 846-856 897-948 977-1014 1033-1048 1072-1079 1196-1202 1290-1295 1353-1384 1463-1469 1539-1542 1550-1606 1760-1768 1811-1818 1825-1835 1854-1859 1931-1952 2006-2010 2123-2131 2185-2195 2296-2303 2347-2375 2417-2465 2511-2547 2926-2934 3365-3545 3555-3565 3601-3614 3801-3807 3910-3913 4323-4340 4370-4377 4410-4439 4803-4834 67-73 78-85 161-161 324-364 384-387 846-856 897-911 921-929 934-948 985-991 997-1014 1033-1036 1290-1295 1353-1365 1539-1542 1550-1556 1567-1586 1605-1606 1760-1768 1811-1818 1825-1835 2123-2131 2296-2303 2371-2375 2417-2418 2460-2465 2511-2522 2926-2934 3376-3413 3463-3468 3510-3545 3555-3565 3601-3609 3910-3913 4323-4340 4370-4377 4410-4427 4803-4807 4817-4834 3953-4318 2961-3326 422-784 1205-1296 4468-4785 1870-1929 2651-2768 2554-2630 422-784 3953-4318 2961-3326 1205-1296 4422-4788 2641-2774 2563-2629 1867-1929 2761-2913 4526-4785 2554-2631 1870-1932 3276-3323 4268-4315 570-620 676-724 4110-4160 3224-3272 4058-4103 4216-4260 3118-3168 3066-3114 3952-3997 2803-2911 2705-2745 513-566 569-620 623-672 675-724 1209-1283 1870-1932 2702-2746 3010-3062 3065-3114 3117-3168 3171-3220 3223-3272 3275-3324 4057-4106 4163-4212 4215-4264 4267-4316 4487-4790 4396-4786 2993-3325 3951-4269 424-729 2554-2630 2774-2913 1861-1929 1204-1287 2685-2756 3603-3709 2447-2505 409-776 1204-1290 2729-2913 2945-3326 3589-3709 3938-4323 4420-4788 72-86 197-211 303-316 520-530 630-644 853-865 901-912 957-976 1051-1065 1309-1315 1439-1445 1544-1562 1938-1954 2117-2129 2210-2221 2374-2385 2401-2417 2519-2538 3178-3189 3429-3445 3478-3493 3753-3769 4006-4022 4170-4184 4346-4356 4808-4821 949-976 3kciA(1-366) 0.0 100.0% 3kciA(2-366) 9e-122 56.56% 4l1mA(1-358) 0.0 98.62% 2keoA(1-92) 2e-43 93.48% 1nd7A(55-370) 7e-31 30.49% 3dkmA(16-74) 3e-17 68.33% 4xi6A(13-139) 5e-10 29.92% 2jngA(2-75) 2e-08 38.96% 4l1mA(1-358) 8e-84 98.62% 3kciA(1-366) 2e-59 100.0% 3kciA(2-366) 3e-48 56.28% 2keoA(1-92) 7e-28 93.48% 1c4zA(5-350) 5e-27 19.79% 4xi6A(8-145) 2e-16 27.97% 2jufA(1-64) 5e-15 37.31% 3dkmA(13-74) 4e-14 65.08% 1jhjA(9-161) 2e-10 26.42% PF00632(30-288) 6e-48 40.08% PF11515(1-77) 7e-27 69.23% PF06701(1-63) 3e-16 55.56% PF00415(1-48) 8e-10 54.17% PF00415(1-48) 1e-09 58.33% PF00415(1-49) 2e-08 54.9% PF00415(1-49) 6e-08 55.1% PF00415(1-49) 1e-06 52.94% PF00415(1-49) 5e-06 48.98% PF00415(1-46) 5e-06 45.65% PF00415(1-45) 1e-05 46.67% PF00415(1-49) 2e-05 47.06% PF00415(1-49) 6e-05 40.82% PF00415(1-47) 0.0009 44.68% PF03256(40-152) 2e-08 34.21% PF00569(3-43) 7e-07 51.22% PF00415 0.00061 23.7% PF00415 7.2e-08 36.7% PF00415 2.2e-09 41.8% PF00415 1.5e-08 39.1% PF00173 4e-22 84.1% PF06701 5.6e-41 146.7% PF00569 2e-09 41.9% PF00415 4.6e-06 30.8% PF00415 1.3e-06 32.6% PF00415 6.7e-07 33.5% PF00415 1.2e-10 46.0% PF00415 0.00012 26.0% PF00415 4e-06 31.0% PF00415 1.6e-07 35.6% PF00415 1.7e-07 35.5% PF00415 4.1e-05 27.6% PF00415 2.5e-07 35.0% PF00632 1.5e-67 235.0% 1nd7A(7-371) 2e-78 26.38% 1a12A(48-395) 2e-66 28.85% 1a12A(65-399) 4e-58 23.67% 1a12A(67-399) 5e-51 24.48% 2jngA1(1-74) 8e-31 38.96% 1jhjA(17-161) 1e-18 25.34% 2dk3A1(3-70) 3e-16 60.87% 1awpA(1-83) 3e-14 28.57% 2dipA1(5-74) 1e-11 27.78% 1sfpA(9-108) 2e-08 14.95% 2cpwA1(1-51) 3e-07 20.34% b.69.5 8.5e-85 288.5% d.120.1 4.4e-16 52.3% b.18.1 1.6e-37 124.2% b.69.5 1e-98 336.1% b.23.1 0.00061 12.5% b.69.5 6.8e-102 347.0% d.148.1 7.6e-98 293.5%

Sequence

MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPP
RKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLV
KEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSGISLPPVDKK
SSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASL
FDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQR
GTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICRKDAPHSEGDM
HLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKG
SLQEVIGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD
TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV
ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL
KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV
KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH
CLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCS
EWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQL
HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT
AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE
AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA
SQTVARLKDVARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSP
ELMGVGSLLKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVS
IVLLLSKNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQN
CRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVA
LEAALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYL
AMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLCSH
RRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEVGRLL
LCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGR
SYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRERRKKRVP
KKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHKYK
WLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAS
KNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRMLLEVTFGKLYAWAV
QNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQARFLLVMLSMLTLQHGAN
NLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSG
PELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGK
EGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGV
HAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIALTPQVC
GALSSPQWITLLMKVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKL
FDFLGSLLTTCSSDVPLLRESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWN
GLINKYINSQLRSITHSFVGRPSEGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLG
GQVMHDEFGEGTVTRITPKGKITVQFSDMRTCRVCPLNQLKPLPAVAFNVNNLPFTEPML
SVWAQLVNLAGSKLEKHKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLR
QILSQPAVQETGTVHTDDGAVVSPDLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDK
QELEAAALAVCQCLAVESTHPSSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALP
IVVQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVS
DEYSDEEVVEDVDDAAYSMSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCC
RAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIK
IGDKVRVKASVTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVP
SIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFC
GRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWI
RLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLND
CTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNS
GSLIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGG
SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT
ALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGEL
YTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG
DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG
SDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKP
TLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADS
SAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA
AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVT
PSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSL
LIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVAT
DSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDG
VNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLS
DRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRK
LLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQ
LLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDE
VAKKIRELMADSENMDVLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHN
HRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIG
GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD
RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEAL
QGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV
KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH
CVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK
PASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGP
SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGT
KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPL
LIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWK
QLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHT
HITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDI
PLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD
FVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIA
LTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH

Region:1-4834
Length:4834aa
Label:Full sequence
Reset:click