Input sequence

Protein name Serine/threonine-protein kinase/endoribonuclease IRE1
Organism Homo sapiens Length 977
Disorder content 12.0% ProS content 8.3%
IDEAL NA UniProt O75460

Prediction

Order Disorder ProS BLAST:PDB BLAST:PDB RPS-BLAST:PDB RPS-BLAST:PDB RPS-BLAST:Pfam RPS-BLAST:Pfam HMMER:Pfam HMMER:Pfam RPS-BLAST:SCOP HMMER:SCOP HMMER:SCOP SEG:LCR COILS:coiledCoil TMHMM:TMhelix 0 977 1-6 7-144 145-150 151-321 322-326 327-407 408-424 425-431 432-459 460-468 469-496 497-558 559-729 730-738 739-968 969-977 7-144 151-321 327-407 432-459 469-496 559-729 739-968 1-6 322-326 408-424 460-468 497-558 730-738 969-977 1-6 412-424 460-468 500-517 538-543 548-558 730-738 969-977 563-956 29-368 560-956 29-368 838-954 577-828 571-832 837-963 571-846 22-232 557-863 6-18 469-496 513-530 536-552 957-971 469-496 7-29 3p23A(1-379) 0.0 95.94% 2hz6A(1-253) 6e-132 74.41% 4pl3A(1-380) 6e-157 90.18% 2hz6A(1-253) 5e-74 72.94% PF06479(2-120) 1e-27 50.42% PF00069(7-254) 9e-21 33.33% PF00069 4.1e-42 150.5% PF06479 3.9e-75 260.2% 1nw1A(95-365) 4e-27 7.93% b.70.1 3.9e-28 91.8% d.144.1 1.7e-57 184.1%

Sequence

MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG
SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY
YFHEPPEPQPPVTPDAL

Region:1-977
Length:977aa
Label:Full sequence
Reset:click